Pretreatment prognostic value of dynamic contrast-enhanced magnetic resonance imaging vascular, texture, shape, and size parameters compared with traditional survival indicators obtained from locally advanced breast cancer patients

Objectives: The aim of this study was to determine if associations exist between pretreatment dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)-based metrics (vascular kinetics, texture, shape, size) and survival intervals. Furthermore, the aim of this study was to compare the prognostic value of DCE-MRI parameters against traditional pretreatment survival indicators. Materials and Methods: A retrospective study was undertaken. Approval had previously been granted for the retrospective use of such data, and the need for informed consent was waived. Prognostic value of pretreatment DCE-MRI parameters and clinical data was assessed via Cox proportional hazards models. The variables retained by the final overall survival Cox proportional hazards model were utilized to stratify risk of death within 5 years. Results: One hundred twelve subjects were entered into the analysis. Regarding disease-free survival-negative estrogen receptor status, T3 or higher clinical tumor stage, large ( > 9.8 cm 3 ) MR tumor volume, higher 95th percentile ( > 79%) percentage enhancement, and reduced ( > 0.22) circularity represented the retained model variables. Similar results were noted for the overall survival with negative estrogen receptor status, T3 or higher clinical tumor stage, and large ( > 9.8 cm 3 ) MR tumor volume, again all been retained by the model in addition to higher ( > 0.71) 25th percentile area under the enhancement curve. Accuracy of risk stratification based on either traditional (59%) or DCEMRI (65%) survival indicators performed to a similar level. However, combined traditional and MR risk stratification resulted in the highest accuracy (86%). Conclusions: Multivariate survival analysis has revealed thatmodel-retained DCEMRI variables provide independent prognostic information complementing traditional survival indicators and as such could help to appropriately stratify treatment

XLV. Osmotic pressure from the standpoint of the kinetic theory

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The church and Venetian political change in the later cinquecento

Chapter I: The Interdict and Changes in Venetian Policy: Illusion and Reality. Introduction: this study is a polemic, attacking the connection usually drawn between the political reform of 1582-3 and the hardening of Venetian attitudes towards the Curia up to 1606. (i) Venetian support of the French Crown in the 1530s and '90s was consistent with previous policy, and was dictated by changes in France rather than in Venice. (ii) Venetian suspicion of Papal jurisdictional claims long predates 1582: some cases show a milder attitude after that reform than before. (iii) The tolerance allowed by Venice to German Protestants did not alter substantially between 1560 and 1606. The growth of the Greek community in the last quarter century can be attributed to external circumstances rather than a more liberal Venetian attitude. The features generally cited to show a change in the direction of Venetian policies are not strong enough to prove it by themselves. Chapter II: A Manifesto for Reform? The literary history of Paruta's "Perfettiono della vita politica" appears to suggest a connection with political change: but the ideas it contains are too ambiguous to have had much partisan appeal. The division of opinions which the dialogue seems to suggest is uncertain, as is its connection with contemporary political events. Chapter III: The Problem and the Reform. The Council of X and Zonta cannot be described as "purely oligarchic" institutions, though their composition and some of their actions in the pre-reform period excited suspicion. The progress of the 1582-3 reform shows no sign of an organised programme or a shared ideology: all practical proposals for reform came from those who wished to preserve the Zonta, and even in opposition to these proposals no consistency was shown. It is not possible to identify a homogeneous group of "reformers". Chapter IV: Reform or Reshuffle? The tenure of the main political offices was in no way altered by the reform. The family interestgroups, particularly Tiepolo-Soranzo, Foscarini-Barbaro-Zustiniani, and Priuli, largely retained through the College the influence they had previously exercised through the X and Zonta. Legislation suggests fiercer competition for a smaller number of influential posts. The ruling clique may have been narrowed by the reform. Chapter V: Property and the Church-Economic Background. The most obvious changes in Venetian policy towards the Church are in the economic field. Growing numbers of nobles hold land from clerical proprietors. Anxieties of Sarpi and Querini about ecclesiastical wealth are born out by the evidence of the previous century: clerical property was growing, but at an uncertain rate and to an unascertainable level. The taxation system put most of it out of the reach of the secular government at a time when ready money was badly needed. Chapter VI: Property and the Church - from Principle to Policy. In the 1560s and '70s, Venetian argument about clerical wealth and privilege was either on an entirely abstract level, discussing canon and civil law, or an entirely parochial level, discussing the vested interests of individuals. Only in the later"1580s does the argument from "state interest" appear. In 1591 famine forced Venice to assert absolute control over property and produce in the Doninio, and this became established policy in 1593-5. This, is the political attitude which led to the property laws of the early XVIIth century, and so to the Interdict. Conclusion: The Venetian governing group did not change materially, but its attitudes did. This resulted more from pressure of economic circumstances around 1591 than from an infusion of new ideology in 1582. Appendix I: Lists of the Council of X (1572-192), Zonta (1572-1581), Savii Grandi (1572-1602) and Savii di Terraferma (1572-1602). Appendix II: Thirty leading senators, their political careers and.. connections, and their economic commitments.. Appendix III: "Alvise Michiel"

Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts

By use of a rapid technique, initial rates of D-glucose transport were obtained during the lifespan in vitro of a commercially available strain of human embryo lung fibroblasts (Flow 2000). The apparent Km of the D-glucose carrier did not change during senescence in vitro: = 1.8 mM (range 1.3-2.3) in phase II, = 1.8 mM (range 1.5-2.2) in phase III. Transport rates remained constant in stationary phase II cultures, which had completed between 30% and 80% of their replicative lifespan. A wide variation, however, was observed in terminally differentiated cells (phase III), which showed a two- to threefold increase in average cell size and protein content. In some senescent cultures, glucose transport calculated on a per cell basis was also two-to threefold increased, while it was strongly decreased (-75%) in others. When calculated per unit of cell water, protein, and surface area, respectively, transport rates in phase III cultures ranged from values established for stationary phase II cultures down to very low values. Detaching cells flushed off from senescent cultures did not show measurable rates of glucose transport into the inulin impermeable cell space. Present evidence argues against the idea that an impairment of D-glucose transport might precede loss of replicative potential in aging human fibroblasts. Instead our data indicate that the transport capacity of cell membrane finally decreases during postreplicative senescence in terminally differentiated cells

Fast, Interactive Worst-Case Execution Time Analysis With Back-Annotation

Abstract—For hard real-time systems, static code analysis is needed to derive a safe bound on the worst-case execution time (WCET). Virtually all prior work has focused on the accuracy of WCET analysis without regard to the speed of analysis. The resulting algorithms are often too slow to be integrated into the development cycle, requiring WCET analysis to be postponed until a final verification phase. In this paper we propose interactive WCET analysis as a new method to provide near-instantaneous WCET feedback to the developer during software programming. We show that interactive WCET analysis is feasible using tree-based WCET calculation. The feedback is realized with a plugin for the Java editor jEdit, where the WCET values are back-annotated to the Java source at the statement level. Comparison of this treebased approach with the implicit path enumeration technique (IPET) shows that tree-based analysis scales better with respect to program size and gives similar WCET values. Index Terms—Real time systems, performance analysis, software performance, software reliability, software algorithms, safety I

\u3cem\u3eAlectryon vitiensis\u3c/em\u3e: A New Species of Sapindaceae Endemic to Fiji

A new species of Alectryon Gaertn. (Sapindaceae) endemic to the Fijian archipelago is described as A. vitiensis Buerki, Lowry, Munzinger & Callm. based on morphological and molecular evidence. It can easily be distinguished from the two congeners currently known from Fiji by its smaller leaves, subsessile leaflets, apetalous flowers, and crested fruits. A phylogenetic analysis using ITS sequence data shows that the new species is closely related to two Australian endemics, A. diversifolius (F. Muell.) S. T. Reynolds and A. oleifolius (Desf.) S. T. Reynolds, but differs in having compound leaves covered with a golden indument. Moreover, the Australian taxa are associated with dry habitats, whereas the new species from Fiji is confined to evergreen humid forests. Among apetalous species (all of which belong to a well-supported clade), A. vitiensis morphologically most closely resembles the generic type, A. excelsus Gaertn., endemic to New Zealand, but they differ from one another in the type of indument covering their branches and leaves and the arrangement, shape, and nature of the indument on their leaflets; and they belong to different clades. The new species is provisionally assigned a conservation status of “Endangered” according to the IUCN Red List criteria

Control ambiental de la fase macroscópica de Nemalion helminthoides (Rhodophyta) en el campo

In temperate areas, lack of nutrients during summer, particularly N, is the main limiting factor of macroalgal growth. However, Nemalion helminthoides (Velley) Batters in northern Spain is conspicuous in the field during this time (from mid-May to late-July). Therefore, we assumed that its nutrient requirements are low enough to be sustained by transient nutrient inputs and we hypothesized that the physiological condition of the thalli was transiently improved when nutrient pulses occurred. A range of proxies for physiological condition (internal N, C, proteins and phycobilins), growth and phenological status of N. helminthoides were measured over time and related to temporal variations in nutrient availability, irradiance, temperature and daylength. Data were analyzed using a multivariate approach (redundancy analysis). Transient nutrient inputs were mainly due to freshwater runoff and wind-driven upwelling events; however, these pulses did not lead to any short-term improvement in the physiological condition of the algae because in such dominant nutrient limiting conditions plants divert transient available resources directly to growth and reproduction. Probably because of the strong endogenous nature of the N. helminthoides life-history, only daylength and temperature were found to be major environmental factors: increasing daylength was associated with growth, sexual maturation, fertilization and the increment of internal N and C, the amount of proteins and phycobilins. Decreasing daylength together with increasing temperature were correlated with spore release and senescence. This research suggests that N. helminthoides requires a high light dose to sustain growth and reproduction, and therefore it must grow and reproduce in summer even though it has to overcome nutrient deprivation during this period.En las costas templadas la falta de nutrientes durante el verano, y en particular la falta de N, es la causa principal de la limitación del crecimiento de las algas. Sin embargo en la costa N de España Nemalion helminthoides (Velley) Batters aparece precisamente durante esta época del año, desde mediados de mayo a finales de julio. Por ello se asume que sus requerimientos de nutrientes son lo suficientemente bajos como para aprovechar pulsos ocasionales, y se plantea la hipótesis de que la condición fisiológica del talo mejora durante la ocurrencia de estos pulsos. Para comprobar esta hipótesis se midieron indicadores de la condición fisiológica tales como el contenido interno de N, C, proteínas y ficobilinas, además del crecimiento y del estado fenológico a lo largo del periodo de crecimiento estival, que se han relacionado con variaciones temporales en disponibilidad de nutrientes, irradiancia, temperatura y fotoperiodo. Los datos se analizaron utilizando una aproximación multivariante (Análisis de Redundancia). Los pulsos ocasionales se debieron fundamentalmente a aportes fluviales y fenómenos de afloramiento costero, pero éstos no produjeron ninguna mejora a corto plazo en la condición fisiológica porque la limitación experimentada por las plantas hizo que éstas dedicaran los recursos disponibles directamente a crecimiento y reproducción. Probablemente, dado el estricto control endógeno del ciclo de vida de N. helminthoides, solamente el fotoperiodo y la temperatura aparecen como factores ambientales importantes: el aumento del fotoperiodo se asocia con el crecimiento, la maduración de las estructuras reproductoras, la fecundación y los aumentos de los contenidos celulares de N, C, proteínas y ficobilinas. El descenso del fotoperiodo en julio, unido al aumento de temperatura, se correlacionó con la liberación de las esporas y la senescencia. Estos resultados sugieren que la especie necesita altos niveles de irradiancia para mantener el crecimiento y la reproducción, lo que obliga a las plantas a crecer y reproducirse en la época estival, aunque teniendo que superar al mismo tiempo la situación de disminución de disponibilidad de nutrientes

Advice for Athletes During Covid-19

This document aims to provide psychological support and guidance for athletes during the current Covid-19 pandemic. Since 23 March, lockdown in the United Kingdom has meant extreme changes and athletes have been forced to significantly alter their training and competition routines. These changes can lead to feelings of anxiety, frustration, and anger for some, and this guidance aims to help alleviate these emotions. The Covid-19 lockdown can be called a non-normative transition* (c.f.2) in sport, this means that it was unexpected and could not be prepared for. This can make it more difficult to manage, and have negative consequences for mental health and psychological wellbeing. This Covid-19 transition will be overwhelming for some – posing many questions around the uncertainty of how long the lockdown period will last, the effect of lockdown on long-term goals for training and competition, and further doubts about what the transition process of emerging from lockdown will look like. We will offer psychological advice to help you deal effectively with the Covid-19 transition, and to place you in a better position to deal with the psychological and behavioural challenges the current situation poses, regardless of when, and if, you return to sport. Three key priorities have been identified which have been shown to be critical for managing transitions, such as the Covid-19 transition